The neurobiology of eating disorders Tips from the parents at the Around the Dinner Table forum * Many parents speak of the importance of the “Minnesota Study” in their understanding of how many of the symptoms once thought to be primary features of anorexia nervosa are actually symptoms of starvation. Studies have shown that starvation leads to behavioral changes regardless the cause. Many parents advise this link to the study: Effects of Semi-Starvation . * One parent has shared recent research about how serotonin regulation is increasingly viewed as a significant pathway in the etiology of eating disorders, "The neurotransmitter serotonin is known to affect appetite control, sexual and social behavior, stress responses, and mood . Serotonin modulates feeding by producing the sensation of fullness or satiety. ... Decreases in brain serotonin function are associated with depression, impulsivity, and aggressive behavior. The major serotonin metabolite, hydroxyindoleacetic acid, is low in people who are underweight with anorexia… * Another parent shares that Harvard Medical School is investigating “The secretory dynamics of leptin in adolescent girls with anorexia nervosa and healthy adolescents * Good summary of research from NIMH * “At one of our Mandometer meetings we attended…research on leptin and ghrelin was discussed. * For those parents seeking a better understanding of neurobiology and nutrition, a parent pointed to an article available here . * More discussion of Leptin’s possible role can be found on the thread "Is this the clue we've been looking for ?" * Another parent shared this study on nutrition and depression . * Examining fatty acid depletion, as a risk factor for depression * And parents have shared studies pointing to PANDAS [pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections] as a trigger in the development of eating disorders in some children. “My d. had PANDAS AN, coming on very suddenly almost exactly three years ago. At that time, there was only a little research and almost no one knew about it--we found it through a lucky combination of circumstances .